Product Name : SIP Fermentation System (Pilot Scale), FS-10L/ FS-30L / FS-50L
Product Description

(FS-10L / FS-30L / FS-50L) Pilot bioreactor(In situ Sterilizable)

Product Introduction

The 10L / 30L / 50L SIP Pilot Scale Fermentation Systems allow you to run small volume of fermentation experiment with ease. These systems are perfectly suitable for small scaling up in the academic lab. The easy programming and operation on our Winpact software put your operation procedure in your peace of mind. System comes with rolling wheels for mobility. All materials are made from the highest standard to ensure optimization of your fermentation process. A variety of optional devices are also available for selection to maintain your optimum performance.


A.Harvest valve:  sterilizable, diaphragm-type tank bottom valve for sanitary post-process harvest

B.Sampling valve: steam-sterilizable valve permits repeatedly sanitary sample collection


B1.Motor - Manual or automatic control of constant agitation speed.

B2.Stainless Steel - Vessel Special designed heating jacket provides better heating efficiency

B3.Peristaltic Pump - Uses four Watson Marlow built-in peristaltic pumps for all your feeding needs

B4.Control Station - Large screen and graphical user interface


Major Science SIP Fermentation Systems

•  Wide range of vessel selection, from 10 L to 50 L working volume
•  Multi-lingual 10.4” and above colored graphical control interface
•  Fully automated process with remote monitoring
•  15-step automatic program setting
•  Orbital welding ensures minimal residue buildup
•  Highest grade construction with 316L stainless steel
•  Jacket design provides astounding temperature control
•  Exhaust pressure relief valve for maximum safety precaution
•  Multiple safety design integration for peace of mind operation
•  Remote monitoring & controlling software free from purchase
•  Password protection for multiple users with customized access levels
•  Various optional devices for process optimization and needs
•  Ethernet communication with Winpact SCADA software, and IP address





Four-staged DO cascade


15-Step programmable PID control

Immediate visualization on operation overview

Easy and intuitive operation for manual and sequence control




One-Touch automatic sterilization for

vessel and system tubing

Online system calibration with

system feedback

System expansion with various

optional devices

*Technical specification subject to change without notice.
*All images are for reference only, actual products might differ from the pictures above.


10 L

30 L

50 L

Total volume

15 L

42 L

67 L

Working volume

10 L

30 L

50 L

Vessel and jacket maximum working pressure

3 bar (43.5 psig) / 4 bar (58 psig)


Double layered fully enclosed capsule-type tank


Direct contact to medium - 316L stainless steel; all others - 304 stainless steel

Surface finish

Interior polish  25 Ra/in (0.6 μm) Mechanical polishing; Electropolish optional
Exterior polish 
 32 Ra/in (0.8 μm) Mechanical polishing; Electropolish optional


Ports designed according to user requirements

Piping and valve materials

Parts that directly contact with the product/medium uses 316L stainless steel (≤25 Ra/in) internal polished tubing (BPE standard) :
A.) Internal EP polished diaphragm type pneumatic valve and manual valve (BPE standard)
B.) Tubing all welded with orbital welding
C.) Vessel bottom drain uses a diaphragm valve, to minimize dead volume
D.) Piping designed for ease of transfer to scale up (can be used as a seed fermentation system) or downstream process

Parts that do not directly contact product/medium
A.) Constructed with 304 stainless steel


10.4” color industrial touch screen

* User-friendly, graphical control interface
* Includes secure user accounts, with different levels of access
* Use stainless-steel controller cabinet (100 L and above only)
* Modularized and standardized design (Module Skid): ergonomically designed according to height, ease of vessel clean up,  and ease of extraction in relation to vessel bottom valve
* Includes maintenance page with system diagnostics
* All programmed setting values are automatically stored into the built-in memory; the settings will not be lost in case of power outage/interruption. When power is restored, the interrupted process will automatically resumed


* Automated sterilization process
* Automated fermentation program


* Control range: 0-100%, adjustable

* Software electrode calibration, with automatic temperature compensation function
* Includes one set of side-inserted stainless steel autoclavable DO electrode

* DO Stat features with intelligent feeding


* PID control with adjustable deadband
* Control range 2.00 to 12.00 pH, ±0.01
* Calibration function with automatic temperature compensation function
* Includes one set of side-inserted, autoclavable pH probe with stainless steel housing

* pH Stat features with intelligent feeding


* Built-in peristaltic pumps

* Each feeding pump can run adjustable 15-step program
* Each pump can be adjusted for speed, forward and backward direction, and manual or automatic mode
* Each of the four peristaltic pumps can be designated for different functions: acid pump, base pump, antifoam pump, or substrate feeding pump
* Optional fifth and six peristaltic pump available


* Vessel temperature is measured with a side-inserted PT-100 temperature probe and maintained using PID control.
 Measure range: 0-130℃, ±0.1℃, Operational range: 0-60℃, ±0.1℃.


* Manual or automatic control of agitation speed
* 15-step program to change speed, or use DO cascade control

Air supply and exhaust

Gas supply and dehumidifer: uses in-house air compressor or air dehumidifier
* Includes re-useable, autoclavable 0.2μm air filter for gas inlet
* Gas Inlet (air) Includes mass flow controller:
    2 vvm maximum according to the vessel capacity
* Gas Inlet (oxygen) Includes pure oxygen rotameter (manual flow control):
   1 vvm maximum according to the vessel capacity
* Includes oxygen gas solenoid valve, with automatic pulsed time control

Air outlet / Exhaust
* Exhaust port with stainless steel condenser
* Includes re-useable, autoclavable 0.2μm air filter
* Includes automated adjustable gas outlet valve to adjust vessel back pressure
* Can control manually or automatically via software

Utility Requirement


10 L

30 L

50 L


Three phase 220V or 380V (note: can be customized to local standard)


At least 6 bar

30 L/min

flow rate

90 L/min

flow rate

150 L/min

flow rate



Peripheral factory water supply

Cooling water (tap water, at least 15oC below working temperature, must be soft water) ;
Pressure at least 2 bar

Process water

RO Water

Plant steam

≥ 2 bar; dry steam with no entrained condensate

Process steam

≥ 2 bar; dry steam with no entrained condensate


In situ drain; ≥ 1"

*Customization on the SIP Fermentation system available upon request.

*Please contact your regional manager for evaluation request.

Catalogue_W04_SIP Fermentation